Please Explain: Alzheimer's Disease and New Alzheimer's Research

Friday, June 21, 2013

Dr. Jerome Groopman, Professor of Medicine at Harvard Medical School, Chief of Experimental Medicine at Beth Israel Deaconess Medical Center, and staff writer for The New Yorker, explains new approaches to Alzheimer’s research for this week’s Please Explain. Three decades of Alzheimer’s research has brought few results in changing the course of the disease, and there have been few developments in drugs to reverse or slow cognitive decline. In his latest article, “Before Night Falls,” in the June 24 issue of The New Yorker, he looks at the potential of new studies.


Dr. Jerome Groopman

Comments [8]


I respect Dr Groopman is a wonderful spokesman for HIV/AIDS and Cancer. I wish that you interviewed the many excellent neurologists and neuropsychologists that deal with Alzheimiers Disease in this city everyday. Alzhemier's is a true defination of a deadly disease. It is also a disease that presents itself with many faces. Dr Groopman did not mention the exciting work being done in cerebral spinal fluid biomarkers as a means for assisting in diagnosis of Mild Cognitive Impairment and Alzhemier's Disease. This may help in the diagnosis of AD before dementia is present . There is also positive new clinical trials studying the use of a glucose nasal spray to increase gluscose levels in the brains of patients with MCI /AD. Overall the interview was timely and important. This disease cares much stigma and misinformation that truly burdens people with Alzhemier's and carepartners of people with Alzhemier's Disease. I am relatively young and functioning well with early stage Alzhemier's and truly appreciate that this disease of the brain is being addressed on WNYC.

Jun. 21 2013 08:30 PM
Amy from Manhattan

Ginkgo biloba has been found to cause cancer in lab animals. The Center for Science in the Public Interest is trying to get the FDA to ban it. Their website has info on this at (FDA Urged to Prohibit Sale of Ginkgo in Wake of Cancer Study).

And there are things people can do about Alzheimer's. There's evidence that exercise and anti-inflammatory drugs can slow progression of the disease.

Jun. 21 2013 02:14 PM
Wayne Johnson Ph.D. from Bk

Jerome Groopman is a sensational writer and a truly great Doctor. I am sorry he cites studies where mice have their brains damaged. Alzheimer's is a terrible plague and rodents want to live as much as you and I. They should not be exploited in this way for alleged human scientific progress.

Jun. 21 2013 02:04 PM

Low rate in India related to turmeric ?

Jun. 21 2013 01:55 PM
Bill G from Danbury

Just heard something about bradykinin B1 receptor in mice?

Jun. 21 2013 01:47 PM

Differential Diagnosis

What's the difference in symptoms between Alz and other dementias?

For example, between Alz and Parkinsonian dementia symptoms?

Jun. 21 2013 01:39 PM
michael from NYC

My 83-yo father has dementia. He has virtually no memory loss, rather he just respins and conflates his life story in non-sensical sentences. This is attended by visual hallucinations. Does Alzehimer's dementia (and Tau Protein) manifest itself in this manner?

Jun. 21 2013 01:34 PM

To what degree can factors like hearing loss, vision impairment, long-term grief/depression, and excessive alcohol intake mimic early Alzheimer's? How do doctors distinguish early Alzheimer's vs. mild cognitive impairment vs. non-Alzheimer's dementia?

And if you don't mind: How does a family member know when to stop allowing a child to ride in a car that an elderly parent is driving?

Thank you for this segment!

Jun. 21 2013 12:12 PM

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