Mayor Michael Bloomberg says the fact that officers are recovering fewer guns through stop-and-frisks is an indication the program is working.
The NYPD program has drawn criticism from civil liberties advocates.
But Bloomberg said on his weekly WOR Radio appearance Friday he believes the stop-and-frisk program is lowering the city's crime rate.
The mayor conceded it could be applied more selectively. He said Police Commissioner Raymond Kelly is always reviewing his procedures and could make changes to the program.
Earlier this week, civil rights groups announced a lawsuit against a program allowing officers to patrol private apartment buildings and perform stop-and-frisks there.
Last year, officers stopped and questioned 684,330 people on the streets under the stop-and-frisk program, a record since the NYPD began tallies in 2002.