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May 12, 2008 | 50°F Clear sky

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cells (shammonds/flickr)

Life's Limit

Until Leonard Hayflick came along, everyone thought cells were immortal. That they’d divide over and over again, forever. Hayflick torpedoes that theory and proved that there is limit. A very predictable limit: a magic number. To thank him, science textbooks everywhere now refer to that as ‘the Hayflick limit.’

While Hayflick’s discovery may seem like a buzzkill for those in search of immortality… fear not! Rules were meant to be broken, and Hayflick, now a Professor of Anatomy at the University of California, points out how one might tinker with this limit in the lab…and the potential dangers of doing so. The limit is different, it turns out, for different animals. There are tortoises that live for centuries, and lobsters that seem to be ageless.

Hayflick's book: How and Why We Age
Slideshow: Dr. Carrell


Listener Comments Comment | Refresh | Back to Episode
[1]
Posted by: angie
August 16, 2007 - 12:49PM

THANK YOU so much for having Leonard Hayflick on your show. He has been one of my scientist heroes for a long time, and is the reason I am working in cellular aging. Each one of your episodes seems eerily entwined with my particular research interests. three cheers for this podcast

[2]
Posted by: Josh
September 19, 2007 - 12:51AM
San Diego CA

I would like to second Angie's comments. I have used WI-38 cells in my own research never knowing that this was the same cell line in which Leonard Hayflick first observed his eponymous limit. It was a thrill to hear his story... from him! Great podcast; it makes commuting fun.

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