Radio Deluxe with John Pizzarelli has enjoyed visits from many a memorable guest since its debut on December 3, 2005. Regis Philbin and dropped by on Christmas weekend; Janis Siegel, of the Manhattan Transfer, brought biscotti; Margaret Whiting broke into a live song about her "Uncle Johnny" Mercer. Other past guests include; Liza Minnelli, Keely Smith, Stacey Kent, Tony Danza, and of course, the members of the John Pizzarelli Quartet.
"Among radio's greatest pleasures is each weekly installment of Radio Deluxe, two hours of great jazz and smart, sassy repartee from John Pizzarelli and Jessica Molaskey, the hippest husband-and-wife team since Louis Prima and Keely Smith. " – Christopher Loudon, Jazz Times